Are the deficits in navigational abilities present in the Williams syndrome related to deficits in the backward inhibition?

Williams syndrome (WS) is associated with a distinct profile of relatively proficient skills within the verbal domain compared to the severe impairment of visuo-spatial processing. Abnormalities in executive functions and deficits in planning ability and spatial working memory have been described. However, to date little is known about the influence of executive function deficits on navigational abilities in WS. This study aimed at analyzing in WS individuals a specific executive function, the backward inhibition (BI) that allows individuals to flexibly adapt to continuously changing environments. A group of WS individuals and a mental age- and gender-matched group of typically developing children were subjected to three task-switching experiments requiring visuospatial or verbal material to be processed. Results showed that WS individuals exhibited clear BI deficits during visuospatial task-switching paradigms and normal BI effect during verbal task-switching paradigm. Overall, the present results suggest that the BI involvement in updating environment representations during navigation may influence WS navigational abilitie

Dynamics of stripe patterns in type-I superconductors subject to a rotating field

The evolution of stripe patterns in type-I superconductors subject to a rotating in-plane magnetic field is investigated magneto-optically. The experimental results reveal a very rich and interesting behavior of the patterns. For small rotation angles, a small parallel displacement of the main part of the stripes and a co-rotation of their very ends is observed. For larger angles, small sideward protrusions develop, which then generate a zigzag instability, ultimately leading to a breaking of stripes into smaller segments. The short segments then start to co-rotate with the applied field although they lag behind by approximately $10^\circ$. Very interestingly, if the rotation is continued, also reconnection of segments into longer stripes takes place. These observations demonstrate the importance of pinning in type-I superconductors.Comment: To appear in Phys. Rev.

Regulation of the expression of the Kluyveromyces lactis PDC1 gene: carbon source-responsive elements and autoregulation

The yeast Kluyveromyces lactis has a single structural gene coding for pyruvate decarboxylase (KIPDC1). In order to study the regulation of the expression of KIPDC1, we have sequenced (EMBL Accession No. Y15435) its promoter and have fused the promoter to the reporter gene lacZ from E. coli. Transcription analysis in a Klpdc1 delta strain showed that KIPDC1 expression is subject to autoregulation. The PDC1 gene from Saccharomyces cerevisiae was able to complement the Rag- phenotype of the Klpdc1 delta mutant strain and it could also repress transcription of the KIPDC1-lacZ fusion on glucose. A deletion analysis of the promoter region was performed to study carbon source-dependent regulation and revealed that at least two cis-acting regions are necessary for full induction of gene expression on glucose. Other cis-elements mediate repression on ethanol

Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation

PURPOSE: To report the management of a case of corneal melting two weeks after pterygium excision with intraoperative topical mitomycin C (MMC). METHODS: Case report. RESULTS: A 57-year-old male was referred to our Department for therapy of rapidly progressive corneal melting two weeks after primary pterygium surgery with MMC (0.2 mg/ml) in September 2009. Initial treatment consisted of topical and systemic immunosuppression along with topical antibiotics. Eight days after presentation, the patient underwent successful lamellar keratoplasty and amnion membrane transplantation. Subconjunctival injection of triamcinolone (40 mg/ml) and topical bevacizumab were used to manage the increased fibrovascular activity around the site of the former pterygium. CONCLUSION: Topical use of MMC during pterygium surgery may be related to serious postoperative complications such as progressive inflammatory corneal melting. The etiology may be multifactorial, which is related to MMC-induced inflammation and/or induced apoptosis. A therapeutic option is the described combination of systemic and local anti-inflammatory treatment along with lamellar keratoplasty and amniotic membrane transplantation. Adjunctive therapy may be needed if recurrence occurs

Learning by observation: insights from Williams syndrome.

Observing another person performing a complex action accelerates the observer's acquisition of the same action and limits the time-consuming process of learning by trial and error. Observational learning makes an interesting and potentially important topic in the developmental domain, especially when disorders are considered. The implications of studies aimed at clarifying whether and how this form of learning is spared by pathology are manifold. We focused on a specific population with learning and intellectual disabilities, the individuals with Williams syndrome. The performance of twenty-eight individuals with Williams syndrome was compared with that of mental age- and gender-matched thirty-two typically developing children on tasks of learning of a visuo-motor sequence by observation or by trial and error. Regardless of the learning modality, acquiring the correct sequence involved three main phases: a detection phase, in which participants discovered the correct sequence and learned how to perform the task; an exercise phase, in which they reproduced the sequence until performance was error-free; an automatization phase, in which by repeating the error-free sequence they became accurate and speedy. Participants with Williams syndrome beneficiated of observational training (in which they observed an actor detecting the visuo-motor sequence) in the detection phase, while they performed worse than typically developing children in the exercise and automatization phases. Thus, by exploiting competencies learned by observation, individuals with Williams syndrome detected the visuo-motor sequence, putting into action the appropriate procedural strategies. Conversely, their impaired performances in the exercise phases appeared linked to impaired spatial working memory, while their deficits in automatization phases to deficits in processes increasing efficiency and speed of the response. Overall, observational experience was advantageous for acquiring competencies, since it primed subjects' interest in the actions to be performed and functioned as a catalyst for executed action

Spectral Relaxations and Fair Densest Subgraphs

Reducing hidden bias in the data and ensuring fairness in algorithmic data analysis has recently received significant attention. In this paper, we address the problem of identifying a densest subgraph, while ensuring that none of one binary protected attribute is disparately impacted. Unfortunately, the underlying algorithmic problem is NP-hard, even in its approximation version: approximating the densest fair subgraph with a polynomial-time algorithm is at least as hard as the densest subgraph problem of at most k vertices, for which no constant approximation algorithms are known. Despite such negative premises, we are able to provide approximation results in two important cases. In particular, we are able to prove that a suitable spectral embedding allows recovery of an almost optimal, fair, dense subgraph hidden in the input data, whenever one is present, a result that is further supported by experimental evidence. We also show a polynomial-time, $2$-approximation algorithm, whenever the underlying graph is itself fair. We finally prove that, under the small set expansion hypothesis, this result is tight for fair graphs. The above theoretical findings drive the design of heuristics, which we experimentally evaluate on a scenario based on real data, in which our aim is to strike a good balance between diversity and highly correlated items from Amazon co-purchasing graphs

Age Diversity Climate Affecting Individual‐Level Work‐Related Outcomes

The present study answers the call for more studies to investigate the age diversity climate’s effect on individual‐level outcomes. Building on the social identity approach and social exchange theory, we surveyed 110 Italian employees aged between 18 and 61 years old (M = 46.10, SD = 10.02) and investigated the role of age diversity climate in predicting intentions to quit (H1), job‐related wellbeing (H2), and work engagement (H3). Our findings confirmed the hypotheses (H1 and H2), showing the added effect of age diversity climate over and above age, job tenure, role clarity, job demands, job control, perceived support, and perceived job and organizational fit. In fact, age diversity climate accounted for a significant increase in the variance explained for two of the three hypothesized models (i.e., intentions to quit and job‐related wellbeing, but not work engagement). To conclude, this study contributes to the existing literature by showing the age diversity climate’s predictive value for turnover intentions and job‐related wellbeing, and corroborating the importance of supporting age diversity through a variety of Human Resources Management strategies

Type-1.5 Superconductors

We demonstrate the existence of a novel superconducting state in high quality two-component MgB2 single crystalline superconductors where a unique combination of both type-1 (kappa_1 0.707) superconductor conditions is realized for the two components of the order parameter. This condition leads to a vortex-vortex interaction attractive at long distances and repulsive at short distances, which stabilizes unconventional stripe- and gossamer-like vortex patterns that we have visualized in this type-1.5 superconductor using Bitter decoration and also reproduced in numerical simulations.Comment: accepted in Phys. Rev. Let